Best MSM - Top 5 in 2026
MSM (methylsulfonylmethane) is an organic sulfur compound found naturally in some plants, fruits and vegetables. This supplement supports joint health by reducing inflammation and pain, supports collagen production to improve the condition of skin, hair and nails, and may alleviate symptoms of seasonal allergies. MSM supplementation can be especially beneficial for people struggling with joint pain, athletes, people with skin problems and seniors concerned about mobility. We encourage you to read the list of the best MSM supplements available on the market, created with the help of our testers. Check out the ranking of the Top 5 supplements containing MSM and choose the product that best meets your needs.
Ranking factors we took into account were:
- Action
- Quality
- Composition
- Format
- Price
- Effects
- Purity
What qualities to look for in good supplements containing MSM?
MSM (methylsulfonylmethane): An essential ingredient that supports collagen and elastin production, reduces inflammation in the body, and supports joint and cartilage health.
Provides the following. Vitamin C: Helps the absorption of MSM and is itself essential for collagen production. Additionally, it enhances the anti-inflammatory effect.
Mineral vitamin. Glucosamine: A natural component of articular cartilage that, when combined with MSM, exhibits stronger joint pain relief and regenerative effects.
Condroitin. Chondroitin: Promotes the elasticity and strength of joint cartilage, and when combined with MSM, forms an effective complex to support joint health.
Collagen. Collagen: Structural protein that supports the rebuilding of connective tissues, and in combination with MSM increases the effectiveness of joint and ligament regeneration.
Collagen. Zinc: Aids in the proper absorption of MSM and supports immune system function.
Provides a range of support for the immune system. Selenium: Promotes the antioxidant effects of MSM and protects cells from oxidative stress.
Bioperin (black pepper extract): Increases the bioavailability of all ingredients, including MSM, improving their absorption in the body.
See our ranking of the best supplements containing MSM:
Nutridome MSM is a dietary supplement containing methylsulfonylmethane - an ingredient that takes care of joint and bone health. Our testers noted the high dosage of methylsulfonylmethane - it is as high as 1,500 mg per day, which, according to the latest scientific research, is the optimal therapeutic value. The organic sulfur contained in MSM acts as a building block of sulfur amino acids, necessary for the synthesis of collagen and keratin. During the month-long treatment, our testers, especially those who attach great importance to physical activity, noted an improvement in joint mobility. An interesting side effect turned out to be the strengthening of hair and nail structure, which confirmed the multidirectional effect of sulfur compounds in the body. The testers appreciated the minimalist composition of the supplement - in addition to active MSM, there were only hydroxypropylmethylcellulose (the shell) and magnesium salts of fatty acids (anti-caking agent). The lack of additives in the form of fillers or preservatives proved to be a hit with people with food allergy tendencies. Testers noted the anti-inflammatory properties of the supplement, which became apparent after about two weeks of use. Reduction of discomfort after intensive training and improvement of tissue elasticity were the main benefits noticed during testing. The pure formulation, ideal dosage and comprehensive effects on the musculoskeletal system make Nutridome MSM a noteworthy proposition for those concerned about joint health and connective tissue health.
MSM by Yango is a tested supplement that contains pure methylsulfonylmethane in powder form, providing 1000-2000 mg of organic sulfur daily. MSM provides bioactive sulfur, which is essential for the synthesis of sulfur amino acids (methionine, cysteine), which in turn are crucial for collagen and keratin production. During supplementation, testers observed an improvement in joint flexibility and a reduction in post-exercise pain in active athletes. An interesting observation was also the strengthening of nail and hair structure in some of the testers. The biggest advantage of the product is its 100% purity - no additives or fillers of any kind. For some of our testers, the powder form proved problematic - it is difficult to measure the dose precisely, and the dissolved MSM leaves an unpleasant, bitter aftertaste. Testers also mentioned the time it takes to prepare the supplement. Some testers also reported temporary stomach discomfort during the first days of use, as well as a characteristic unpleasant body odor - testers described that the skin odor resembled garlic.
Formeds Bicaps MSM is a supplement containing 700 mg of methylsulfonylmethane in capsules made of pullulan, a plant polysaccharide. This organic sulfur compound plays a key role in the synthesis of collagen, keratin and sulfur enzymes. During supplementation, our testers observed a reduction in joint stiffness (in physically active people) after just 10 days of use. MSM showed anti-inflammatory effects, especially in knee joint strain. We also noted an improvement in the condition of hair and nails in a significant proportion of our female testers. Testers did not like the low content of MSM in a single capsule - most clinical studies indicate the effectiveness of doses of 1500-2000 mg per day, which requires taking 2-3 capsules at a time. The testers noted that MSM can exacerbate the effects of anticoagulants, cause allergic reactions, and lead to nausea and diarrhea in sensitive individuals.
Now Foods MSM is a capsule supplement that provides 1,500 mg of methylsulfonylmethane per day - a dose that enables the organic sulfur to be effectively delivered to the body. The compound promotes collagen synthesis in cartilage tissue, improving joint flexibility and reducing pain, as confirmed by most of our testers after 3-4 weeks of use. However, our testers were not satisfied with the presence of stearic acid and microcrystalline cellulose as fillers. Several female testers also complained of an unpleasant aftertaste after swallowing the tablet and difficulty swallowing it due to its size. It is worth noting that MSM can cause adverse reactions: in some testers we observed temporary stomach problems, headaches and skin rashes. There is also a risk of interaction with anticoagulant drugs - MSM can exacerbate their effects. Despite these caveats, the supplement stands out for its certified raw material quality and positive effects on the regeneration of connective tissue, hair and nails.
Solgar MSM is a supplement containing organic sulfur in tablet form. Solgar MSM provides 1,000 mg of methylsulfonylmethane in each tablet, offering a bioactive form of sulfur necessary for the synthesis of sulfur amino acids. Our testers noted that the compound effectively promotes the regeneration of cartilage and connective tissue, resulting in better joint mobility after about three weeks of use. The ladies also appreciated the positive effect on skin condition - two participants observed a reduction in symptoms of inflammatory acne and improved skin elasticity. The group of female testers drew attention to the long list of technological additives - despite claims of a "simple formulation," the product contains cellulose, silicon dioxide and vegetable glycerin as fillers and glazing agents. Also controversial was the high price - almost twice as high as similar preparations of competitors with comparable content of active substance. Our testers also observed characteristic side effects - a methyl aftertaste in the mouth and periodic stomach discomfort when taking MSM on an empty stomach.
