Best supplements with Lion's Mane extract - Top 5 in 2026

Lion's Mane by Aliness is an extract of coneflower that positively benefits the nervous system by stimulating the production of nerve growth factor, resulting in improved cognitive function and memory. The beta-glucans in Lion's Mane further boost immunity by acting as natural immunomodulators that activate macrophages and other immune cells. Polysaccharides exhibit anti-inflammatory and antioxidant properties, protecting neurons from oxidative stress. Our testers noted the relatively low dose of the extract compared to the dose recommended by experts (1000-3000 mg per day) for optimal effects. This means taking 3-4 capsules a day instead of the manufacturer's recommended one. Although the formulation is pure and suitable for vegans, the product does not provide information on the standardization of hericenone and erinacin, which are the key compounds responsible for Lion's Mane's neuroprotective effects.

Formeds Bicaps Lion's mane is a supplement that offers easy-to-swallow plant capsules. Our testers appreciated the product's pure formulation, containing only Lion's mane extract without fillers or unnecessary chemicals. The 150 mg of polysaccharides in each capsule provides visible effects in improving cognitive function and reducing stress. The positive effect on digestion was especially appreciated - several testers noticed a reduction in gastric discomfort after several days of use. The disadvantage of the supplement turned out to be insufficient concentration of the extract compared to other products on the market, making the time to wait for the effects quite long. Users were also critical of the incomplete information on the content of key active substances, especially beta-glucans and the level of erinacins, which are the main components responsible for the protection and regeneration of nerve cells. In addition, an unpleasant surprise for many was the price of the product - clearly higher than the market average while providing fewer active substances per capsule.

Yango Hericium is an advanced supplement containing a high dose of Hericium extract. The 20:1 extract provides a concentrated form of bioactive compounds that effectively support cognitive function by stimulating the production of nerve growth factor. The product has the advantage of containing natural polysaccharides and beta-glucans, which exhibit immunomodulatory and neuroprotective effects. They intensify the regeneration of nerve cells, which translates into improved memory and concentration. Testers also noted a positive effect on intestinal microflora. Our testers drew attention to the packaging, which, in their opinion, does not sufficiently protect against moisture, which can reduce the quality of the supplement with prolonged storage. In addition, the lack of precise information about the actual beta-glucan content undermines the reliability of the extract's standardization. The quality-to-price ratio also leaves much to be desired compared to other supplements containing Lion's Mane.

Lion's Mane by Swanson is a supplement based on powdered mycelium of coneflower, rather than an extract, which significantly affects its effectiveness. A dose of 500 mg of pure mycelium provides only small amounts of active compounds - beta-glucans and polysaccharides, which stimulate the production of NGF (nerve growth factor) protein. The advantage of the product is the use of the whole mycelium, which ensures the presence of the full spectrum of natural bioactive compounds. Our testers noted a mild, gradual effect to support concentration without the effect of sudden stimulation. A significant drawback is the use of gelatin in the capsule formulation, which excludes the product from being offered to vegans. Also of concern is the presence of an undefined "rice extract blend" as a filler. Some of our testers have observed that Lion's Mane can cause side effects in sensitive individuals, such as itchy skin, increased allergic symptoms and digestive disturbances during the initial phase of supplementation, especially with the simultaneous use of anticoagulants.