The best berberine supplement - TOP 5 in 2025
As a natural alkaloid present in many plants, including barberry, goldenrod and long-stemmed oyster, berberine is the subject of ongoing scientific and clinical research. It is known for its versatile health properties. Many years of research have shown that berberine can support heart health, improve glucose metabolism, support the immune system and have antimicrobial and anti-inflammatory properties. Studies have also shown that berberine can help maintain normal blood cholesterol levels, which in turn supports cardiovascular health. In addition, berberine may also protect cells from oxidative stress, which may contribute to its beneficial effects on the heart. Contemporary research suggests that berberine may be particularly effective against bacterial infections, which are becoming increasingly resistant to traditional antibiotics. It is because of these unique properties that berberine is becoming increasingly popular in the supplement world. So we took a look at those available on the market and selected the top 5 according to us.
The ranking factors we took into account were:
- Active ingredients
- Standardisation
- Form of the supplement
- Improved glucose metabolism
- Safety
- Regulation of sugar levels
- Price/performance ratio
What ingredients to look for in a good berberine supplement?
Vitamin C: can help strengthen the immune system and increase the bioavailability of berberine, improving its absorption and utilisation by the body.
Plant extracts: such as Acai berry or green tea extract, can provide additional nutrients and antioxidants, supporting overall health.
Probiotics: the addition of probiotics can support gut health by improving digestion and nutrient absorption, which may improve berberine utilisation.
Unsaturated fatty acids: such as omega-3, may support cardiovascular health, which may further enhance the benefits of berberine.
Take a look at our ranking for the best berberine supplements:
The highly standardised dietary supplement Berberine NUTRIDOME provides natural support for people with sugar disorders. In addition to regulating glucose levels and reducing body weight, it also has the ability to protect cells from oxidative stress. It exhibits anti-cancer and anti-ageing properties and is also an effective blood pressure regulator. It contributes to liver health and metabolic processes. Research has also shown that Berberine can aid weight loss by controlling genes responsible for fat accumulation. It improves insulin sensitivity and facilitates the uptake of glucose by the body's cells. It is valued by people with insulin resistance, who often consider it a natural alternative to metformin. What's more, berberine reduces complications associated with type 2 diabetes. Nutridome's insulin resistance supplement is available in easy-to-swallow capsules and lasts for a month's treatment.
SFD berberine HCL is a supplement product that contains Berberis aristata bark extract. This natural plant alkaloid has gained a reputation as one of the most powerful natural supplements. According to research, berberine can help improve insulin sensitivity. This may be related to its effect on lipogenic genes. In addition, according to many researchers, berberine may act analogously to metformin by directly affecting the activity of an enzyme whose activation results in reduced glucose and fat synthesis. Berberine also shows protective properties for the liver. Thanks to its antioxidant properties and its effect on the activity of enzymes responsible for detoxification, it can help to ensure health and protection for this important organ. The supplement from SDF contains a high dose of berberine per tablet. Because of this, the capsules are quite large and, for some, hard to swallow.
Berberine, as a plant-derived alkaloid, is primarily extracted from various berberis species, which are beneficial for glucose metabolism and support liver health. The plant normalises intestinal function and strengthens the function of the digestive glands. The addition of the standardised thistle extract in the supplement from Yango helps to cleanse the body and supports the liver detoxification process. Berberine stimulates glucose-induced insulin secretion and increases cellular sensitivity to insulin, which has a beneficial effect on blood sugar levels and body weight. Berberine also has an effect on blood levels of triglycerides, total cholesterol and the LDL fraction. One packet of berberine from Yango is enough for a month's treatment. Which makes its price a little too high, which is why it came in third place.
The supplement from Swanson mainly targets the regulation of sugar metabolism. It contains berberine and moringa leaves in the formulation. Berberine supports the maintenance of normal blood glucose levels, helps the body to use insulin better and may support the production of healthy insulin. Moringa leaves are one of nature's main sources of chromium, and research suggests that chromium levels in the body can affect blood sugar levels. Chromium helps the body use carbohydrates to efficiently produce sugar and insulin. Chromium may also support pancreatic cells in the production of insulin. Pure Blood Sugar also contains Gymnema sylvestre GS4 Plus® extract, a clinically tested Ayurvedic herb that supports the body's response to insulin. This herbal trio provides natural support for health and wellbeing. Nevertheless, the manufacturer cautions that it is essential for people with diabetes to consult the use of Pure Blood Sugar with their healthcare practitioner.
Berberine Doctor Life capsules contain an extract with a high concentration of active ingredients from the berberine root. Berberine, a yellow alkaloid that can be found in several different plants, including European Berberis, has antibacterial and anti-inflammatory properties. It is particularly recommended for the treatment of gastrointestinal problems such as diarrhoea and food poisoning. It is involved in complex fatty acid metabolism, lowering blood sugar levels and reducing 'bad' LDL cholesterol. In addition, berberine from Doctor Life has the ability to regulate the digestive system and eliminate indigestion. The Doctor Life brand is unfortunately poorly available both online and in stationary shops.
