The best peptide creams - TOP 5 ranking in 2025
Wrinkles and signs of ageing are natural elements of the skin ageing process that can affect anyone. The formation of wrinkles is often the result of reduced collagen and elastin production, as well as the impact of external factors such as sun exposure, air pollution, diet and stress. Peptide cream provides a cutting-edge solution in the fight against the signs of ageing, offering a concentrated formula that supports skin regeneration and renewal. Peptides, which are short chains of amino acids, help to stimulate collagen production, leading to improved skin firmness and elasticity, as well as a reduction in fine lines and deeper wrinkles. In addition to implementing healthy lifestyle habits, a cream with peptides can significantly improve the appearance of skin, restoring a youthful glow and smoothness. In our ranking, we present five select peptide creams that are highly regarded for their effectiveness in improving skin condition, minimising signs of ageing and providing long-lasting results.
The ranking factors we took into account were:
- Improvement in skin condition
- Anti-wrinkle action
- Composition
- Moisturisation
- Consistency
- Efficiency
- Price
What ingredients to look for in good peptide creams?
Peptides: Peptides are protein fragments that help stimulate the production of collagen and elastin, resulting in improved skin elasticity and firmness.
Hyaluronic acid: This is a compound found naturally in the skin that attracts and binds water. When added to creams, it has a hydrating effect on the skin, giving it a fresh and rested appearance.
Antioxidants: Such as vitamin C, E or coenzyme Q10, are designed to neutralise the action of free radicals, responsible for the skin's ageing process.
Retinol: This is an active form of vitamin A that stimulates collagen production and can help to reduce wrinkles and unify skin tone.
Plant extracts: Depending on the type, may have moisturising, nourishing, anti-inflammatory or toning properties.
Ceramides - strengthen the skin barrier, preventing moisture loss and improving skin condition. Niacinamide (vitamin B3) - helps to strengthen the skin barrier and smooth the skin surface.
Plant butters and oils - (e.g. shea butter, argan oil, jojoba oil) provide deep hydration and nourishment.
Take a look at our ranking of the best creams with peptides:
Orphica presents the Timeless peptide cream set dedicated to mature skin: a day cream with SPF 20 protection and a night cream. This unique Timeless cosmetic set from Orphica has been created to provide the skin with comprehensive protection and care around the clock and a powerful fight against the signs of ageing. The Peptide Day Cream protects skin from harmful UV rays with SPF 20 and contains Pro-Lift Complex to deeply hydrate, smooth and restore skin's firmness for an anti-ageing effect. The night cream enriches the treatment with Cell-Fortifying Complex and ChroNolin peptide to promote nighttime skin renewal, minimising wrinkles, stimulating collagen production and strengthening blood vessels. Each ank's skin is full of radiance, elasticity and a healthy appearance. Timeless Orphica's peptide creams have been extensively tested, confirming their high efficacy in reducing signs of ageing and deeply nourishing the skin, and are safe to use thanks to dermatological and allergy testing.
Estee Lauder, a renowned brand in the world of luxury skincare, offers the Resilience Multi-Effect Night Tri-Peptide cream, ideal for mature skin looking for an effective lift. This peptide cream intensely fights the signs of ageing, reducing wrinkles and preventing the formation of new ones. Users appreciate how regular use of the cream improves skin firmness and smoothness, as well as evening out skin tone. Its rich formula, containing morolistica extract and avocado oil, intensively moisturises and nourishes the skin. The addition of the Tri-Peptide Lift complex stimulates collagen production, increasing skin elasticity. Downsides include the cream's intense fragrance and, typical of the brand, its very high price.
Lancome Renergie H.P.N. 300-Peptide Cream, ranked third in our peptide cream ranking, is an anti-wrinkle day cream that uses patented skin regeneration technology. Enriched with hyaluronic acid, niacinamide and an impressive 300+ types of peptides, the cream effectively accelerates cell renewal, firming the skin in as little as one week. It makes facial contours tighter, wrinkles visibly reduced and the complexion brightened and unified. Despite its noticeable rejuvenating and smoothing effects, this cream is ranked third mainly because of its very high price and the presence of potentially irritating ingredients such as alcohol and isopropyl palmitate, which may not benefit sensitive skin.
Vichy Liftactiv Supreme is a lifting face cream that combines the power of rhamnose, caffeine and collagen peptides, vitamin Cg and niacinamide. The formula is designed to rejuvenate and hydrate the skin. Our testers confirmed that the peptide cream effectively improves the oval of the face, smooths and reduces wrinkles, while evening out the texture of the complexion. Although the product is effective in stimulating collagen production, the formula contains isopropyl isostearate, which can cause irritation in those with sensitive skin. In addition, the texture of the cream may leave a greasy feeling and make-up applied over the cream may roll off. It is also worth noting the price of the product, which can be a deciding factor for potential users.
Apis Lifting Peptide, a lifting and tightening face cream, despite ranking last in our ranking of peptide creams, still offers a range of benefits for skin in need of firming and rejuvenation. Its formula contains hyaluronic acid and cobiolift from quinoa to provide the skin with hydration, lifting and a reduction in fine lines and wrinkles. The SNAP-8™ peptide cream noticeably improves the appearance of the complexion, giving it a healthy and radiant look. However, its main drawbacks, such as low performance and moderate hydration levels, can affect overall satisfaction. If we want to use it at least once a day, the pack will run out after about 6 weeks.
