The best serums for acne - Top 5 2025
Caring for skin with a tendency towards imperfections can be quite a challenge. Fortunately, there are plenty of cosmetics on the market that can help you achieve the skin condition of your dreams. Acne skin serums can be found in any drugstore, however, the wide range of products can make it easy to come across one that does not meet our expectations. Acne serums are distinguished by their high efficacy, although their effectiveness can vary depending on the brand and formulation. We have analysed the composition of many products and tested numerous serums to identify the best ones for you. We present a ranking of the 5 most effective serums for acne in 2025.
The ranking factors we took into account are:
- Effectiveness
- Soothing irritation
- Composition
- Consistency
- Ease of application
- Price
- Undesired effects
What qualities to look for in a good serum for acne-prone skin?
Squalane: This ingredient provides deep hydration to the skin without clogging pores, which is key to keeping the skin healthy while fighting acne.
Niacinamide: Also known as vitamin B3, niacinamide helps reduce inflammation, reduce redness and control the overproduction of sebum, which is key in acne treatment.
Zinc: Has anti-inflammatory and antibacterial properties that help fight acne-causing bacteria and reduce blemishes.
Vitamin B3: Promotes skin regeneration, reduces acne scarring and improves overall skin texture for a healthier appearance.
Oil-free formula: Serums should be oil-free so as not to clog pores and worsen acne problems. Lightweight texture: A lightweight formula that absorbs quickly allows the active ingredients to work effectively without feeling greasy.
Antibacterial ingredients: Ingredients such as salicylic acid can help fight the bacteria that contribute to acne.
Soothingproperties: Serums should contain ingredients that soothe irritation and redness, helping the skin to recover faster and more effectively.
Take a look at our ranking of the best serums for acne:
In first place in our ranking was the acne serum by Nutridome. This is no coincidence, as the product with vitamin B3 and zinc PCA stands out for its exceptional effectiveness. These ingredients even out skin tone, reduce blemishes and help control excessive sebum secretion. After using the serum, the skin is moisturised and pores are visibly reduced. The vitamin content of the serum is also responsible for regulating the sebaceous glands, which translates into lasting effects and a significant improvement in skin condition. With regular use, the acne serum brings relief to the affected skin, reduces inflammation and improves the appearance of the skin. At the same time, it does not cause irritation and is well absorbed. Testers also appreciated the product's efficiency and ease of application thanks to the included pipette. As an acne serum, the product performed excellently.
Skinimal imperfections serum is a dermocosmetic containing 10% niacinamide (vitamin B3) and azeloglycine. The product formula effectively reduces sebum secretion, evens out skin tone and supports the fight against imperfections, especially in oily and acne-prone skin. An additional 1% zinc accelerates skin regeneration and reduces papules. The liquid, gel-like texture of the serum is fragrance-free and absorbs quickly, which was appreciated by our testers. Niacinamide has an antioxidant effect, stimulates collagen synthesis and lightens hyperpigmentation, while zinc has a regenerative and anti-acne effect, reducing irritation and acting as an antioxidant. Testers noted that the serum improves the overall condition of the skin. Although moderate performance and poor sebum-reducing action are drawbacks of this product, it deserved a high second place.
The acne serum by Bielenda Professional is designed to regulate the amount of sebum produced, and thanks to its zinc PCA content, it perfectly manages this task. The product also contains niacinamide, which helps to reduce imperfections, discolouration and wrinkles. Our testers noticed a reduction in sebum and an overall improvement in the appearance of their skin after regular use of the serum. Although the composition of the serum is good and has high efficacy and effectiveness, the product has a rather heavy formula, which can lead to clogged pores with prolonged use. Additional disadvantages are the high price and the inability to see how much product is left in the container due to its watery consistency.
SkinTra Comedo-killer Cleansing Serum contains 2% encapsulated salicylic acid, which allows for a gradual and gentle release of the active ingredient. Our testers appreciated its watery, lightweight texture, which does not weigh down the skin and is absorbed without a trace. The serum effectively exfoliates dead skin, cleanses pores and reduces blackheads, and helps control excessive sebum secretion. Enriched with azeloglycine, gluconolactone and shikimic acid, the serum not only reduces imperfections but also prevents their formation. Although the formula is gentle and non-stinging, some testers noted that the product leaves an oily film on the skin and may not deal with more advanced acne.
Eveline Face Therapy Professional serum is an effective solution for those struggling with skin problems. It contains 10% niacinamide, zinc and salicylic acid, which effectively reduce imperfections and regulate sebum secretion. The product is particularly recommended for oily and combination skin as it evens out skin tone and reduces the appearance of pores. Our testers appreciated the ease of application and the quick absorption of the serum, making it suitable for both morning and evening use. Nevertheless, they noted that the serum is not very efficient and in some cases may not be strong enough to significantly reduce acne. Additionally, the product takes a long time to absorb, which may be inconvenient for some users. On the plus side, however, is the refined bottle, which makes application easy.
