The best supplements for the blues - TOP 5 ranking in 2025
With the increasing pace of life and ever-present stress, the search for effective methods to maintain mental balance is becoming increasingly important. Dietary supplements designed to combat despondency and tension are gaining in popularity, offering natural support to relieve stress. Ingredients such as lemon balm, hops, valerian and ashwagandha, also known as Indian ginseng, are prized for their calming and tension-reducing properties. In response to the growing interest in safe and natural methods of coping with despondency, we have prepared a ranking of the most effective supplements. This ranking is based on the popularity and effectiveness of various products available on the market. We invite you to take a look at our ranking to choose the supplement that best meets your needs and helps you regain your calmness and improve your mood.
The ranking factors we took into account are:
- Mood enhancement
- Composition
- Dosage
- Ease of use
- Efficiency
- No side effects
- Price
What ingredients should good supplements for despondency and mood enhancement contain?
Ashwagandha - a well-known adaptogen, supports the body's adaptation to stress, lowering cortisol levels and increasing resilience to stressful situations, so may be helpful for despondency.
L-theanine - an amino acid from green tea, offering relaxing effects, relieves tension and improves focus, supporting resistance to stress and despondency.
Rhodiola rosea - an adaptogenic plant used in supplementation reduces feelings of stress and fatigue.
B vitamins - including vitamin B5, B6, B9 (folic acid) and B12, support the nervous system to help alleviate the effects of stress.
Magnesium - a key mineral for physiological processes, contributes to stress reduction and improves nervous system function. Its deficiency can cause depressed mood.
Alpha-lipoic acid - acting as an antioxidant, helps regulate oxidative stress and improves brain function.
Omega-3 fattyacids - DHA and EPA, found in omega-3 fats, are key to brain and nerve health, which promotes better stress management.
Probiotics - maintaining gut health is closely linked to mental wellbeing, hence probiotic supplementation can contribute to a better balance of the gut microbiota, which in turn can reduce stress levels and despondency.
Take a look at our ranking of the best supplements for despondency and lowered mood:
NUTRIDOME Ashwagandha is a dietary supplement that effectively supports the fight against despondency, thanks to the natural extract of ashwagandha, a plant that has been appreciated for centuries for its positive effects on physical and mental wellbeing. Considered an adaptogen, ashwagandha helps the body adapt to stressful situations, reducing despondency and improving overall wellbeing. Testers highlighted a significant improvement in mood and a reduction in perceived stress when taking the NUTRIDOME supplement. The benefits of taking ashwagandha regularly also include boosting immunity, supporting muscle mass building, regulating blood sugar levels and improved sleep quality. The daily dose provides 400 mg of ashwagandha extract and is standardised, so we are confident in the composition. NUTRIDOME Ashwagandha offers high efficacy at an attractive price, providing an excellent option for those looking for natural support to relieve stress and improve mood.
Solgar Mountain Rhodiola Rosea is a dietary supplement designed for people experiencing stress-related tension and busy lifestyles who struggle with decreased energy, concentration and despondency. Its main ingredient, Rhodiola Rosea root extract, supports adaptation to emotional stress and physical exertion, improving concentration and alleviating feelings of fatigue. Thanks to the Rhodiolife® formula, the product offers a scientifically tested extract that preserves the natural proportions of important plant compounds such as rosavins and salidrosides. Despite its advantages, users complain about the large tablet size, which makes it uncomfortable to swallow. The high price of the supplement is also a downside - it is the most expensive product on the list.
Depresanum is a dietary supplement designed to support adults experiencing depressed mood and despondency. It contains a combination of ingredients such as inositol, L-tryptophan and saffron flower extract to support wellbeing, emotional balance and nervous system health. Although the product appears to have an effective formulation for mood enhancement, there has been criticism that the doses of inositol and L-tryptophan are too low, significantly reducing its effectiveness. However, despite this, regular use of saffron flower extract for six to eight weeks can produce beneficial effects. It is worth noting that dosage may need to be adjusted for full satisfaction.
Positivum is a dietary supplement in tablets designed to address feelings of nervous tension, which can help reduce stress and despondency. The lemon balm extract it contains helps to maintain a positive mood, while hops cone extract supports healthy sleep. The recommended serving is one tablet three times a day, although the size of the tablets may be a challenge for some users. The majority of testers confirm that Positivum noticeably reduces nervous symptoms and brings relief from the blues. It is a safe and non-addictive product, available in a pack of 180 capsules, which guarantees long-term use. Nevertheless, the presence of colourings and magnesium stearate may be a downside for those looking for supplements with a simple, natural composition.
Offering 250 mg of ashwagandha (Withania somnifera) root extract in each tablet, Himalaya brand Ashwagandha is a dietary supplement designed to combat stress, improve mood and relieve despondency. Despite its attractive price, the product has a very low standardisation of vitanolides, barely over half a per cent, which must negatively affect its effectiveness. The recommended dosage of four tablets per day may be burdensome for some users. Supplements with higher standardisation and a more concentrated dosage may offer better value for money and greater convenience of use.
